Clinical outcomes of current medical approaches for Middle East respiratory syndrome: A systematic review and meta-analysis.
Identifieur interne : 000A39 ( Main/Exploration ); précédent : 000A38; suivant : 000A40Clinical outcomes of current medical approaches for Middle East respiratory syndrome: A systematic review and meta-analysis.
Auteurs : Mostafa Ebraheem Morra [Égypte] ; Le Van Thanh ; Mohamed Gomaa Kamel ; Ahmed Abdelmotaleb Ghazy [Égypte] ; Ahmed M A. Altibi [États-Unis] ; Lu Minh Dat ; Tran Ngoc Xuan Thy ; Nguyen Lam Vuong ; Mostafa Reda Mostafa ; Sarah Ibrahim Ahmed [Égypte] ; Sahar Samy Elabd [Égypte] ; Samreen Fathima [Inde] ; Tran Le Huy Vu [États-Unis] ; Ali S. Omrani ; Ziad A. Memish [Arabie saoudite] ; Kenji Hirayama [Japon] ; Nguyen Tien Huy [Viêt Nam]Source :
- Reviews in medical virology [ 1099-1654 ] ; 2018.
Descripteurs français
- KwdFr :
- Antiviraux (pharmacologie), Antiviraux (usage thérapeutique), Coronavirus du syndrome respiratoire du Moyen-Orient, Facteurs de risque, Femelle, Humains, Infections à coronavirus (mortalité), Infections à coronavirus (traitement médicamenteux), Infections à coronavirus (virologie), Interférons (pharmacologie), Interférons (usage thérapeutique), Mâle, Résultat thérapeutique.
- MESH :
- mortalité : Infections à coronavirus.
- pharmacologie : Antiviraux, Interférons.
- traitement médicamenteux : Infections à coronavirus.
- usage thérapeutique : Antiviraux, Interférons.
- virologie : Infections à coronavirus.
- Coronavirus du syndrome respiratoire du Moyen-Orient, Facteurs de risque, Femelle, Humains, Mâle, Résultat thérapeutique.
English descriptors
- KwdEn :
- Antiviral Agents (pharmacology), Antiviral Agents (therapeutic use), Coronavirus Infections (drug therapy), Coronavirus Infections (mortality), Coronavirus Infections (virology), Female, Humans, Interferons (pharmacology), Interferons (therapeutic use), Male, Middle East Respiratory Syndrome Coronavirus, Risk Factors, Treatment Outcome.
- MESH :
- chemical , pharmacology : Antiviral Agents, Interferons.
- chemical , therapeutic use : Antiviral Agents, Interferons.
- drug therapy : Coronavirus Infections.
- mortality : Coronavirus Infections.
- virology : Coronavirus Infections.
- Female, Humans, Male, Middle East Respiratory Syndrome Coronavirus, Risk Factors, Treatment Outcome.
Abstract
Middle East respiratory syndrome (MERS) is a respiratory disease caused by MERS coronavirus. Because of lack of vaccination, various studies investigated the therapeutic efficacy of antiviral drugs and supportive remedies. A systematic literature search from 10 databases was conducted and screened for relevant articles. Studies reporting information about the treatment of MERS coronavirus infection were extracted and analyzed. Despite receiving treatment with ribavirin plus IFN, the case fatality rate was as high as 71% in the IFN-treatment group and exactly the same in patients who received supportive treatment only. Having chronic renal disease, diabetes mellitus and hypertension increased the risk of mortality (P < .05), and chronic renal disease is the best parameter to predict the mortality. The mean of survival days from onset of illness to death was 46.6 (95% CI, 30.5-62.6) for the IFN group compared with 18.8 (95% CI, 10.3-27.4) for the supportive-only group (P = .001). Delay in starting treatment, older age group, and preexisting comorbidities are associated with worse outcomes. In conclusion, there is no difference between IFN treatment and supportive treatment for MERS patients in terms of mortality. However, ribavirin and IFN combination might have efficacious effects with timely administration and monitoring of adverse events. Large-scale prospective randomized studies are required to assess the role of antiviral drugs for the treatment of this high mortality infection.
DOI: 10.1002/rmv.1977
PubMed: 29664167
Affiliations:
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Altibi</name><affiliation wicri:level="2"><nlm:affiliation>University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Dat, Lu Minh" sort="Dat, Lu Minh" uniqKey="Dat L" first="Lu Minh" last="Dat">Lu Minh Dat</name><affiliation><nlm:affiliation>Online Research Club (http://www.onlineresearchclub.org/).</nlm:affiliation><wicri:noCountry code="no comma">Online Research Club (http://www.onlineresearchclub.org/).</wicri:noCountry></affiliation></author><author><name sortKey="Thy, Tran Ngoc Xuan" sort="Thy, Tran Ngoc Xuan" uniqKey="Thy T" first="Tran Ngoc Xuan" last="Thy">Tran Ngoc Xuan Thy</name><affiliation><nlm:affiliation>Online Research Club (http://www.onlineresearchclub.org/).</nlm:affiliation><wicri:noCountry code="no comma">Online Research Club (http://www.onlineresearchclub.org/).</wicri:noCountry></affiliation></author><author><name sortKey="Vuong, Nguyen Lam" sort="Vuong, Nguyen Lam" uniqKey="Vuong N" first="Nguyen Lam" last="Vuong">Nguyen Lam Vuong</name><affiliation><nlm:affiliation>Online Research Club (http://www.onlineresearchclub.org/).</nlm:affiliation><wicri:noCountry code="no comma">Online Research Club (http://www.onlineresearchclub.org/).</wicri:noCountry></affiliation></author><author><name sortKey="Mostafa, Mostafa Reda" sort="Mostafa, Mostafa Reda" uniqKey="Mostafa M" first="Mostafa Reda" last="Mostafa">Mostafa Reda Mostafa</name><affiliation><nlm:affiliation>Online Research Club (http://www.onlineresearchclub.org/).</nlm:affiliation><wicri:noCountry code="no comma">Online Research Club (http://www.onlineresearchclub.org/).</wicri:noCountry></affiliation></author><author><name sortKey="Ahmed, Sarah Ibrahim" sort="Ahmed, Sarah Ibrahim" uniqKey="Ahmed S" first="Sarah Ibrahim" last="Ahmed">Sarah Ibrahim Ahmed</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Medicine, Cairo University, Giza, Egypt.</nlm:affiliation><country xml:lang="fr">Égypte</country><wicri:regionArea>Faculty of Medicine, Cairo University, Giza</wicri:regionArea><wicri:noRegion>Giza</wicri:noRegion></affiliation></author><author><name sortKey="Elabd, Sahar Samy" sort="Elabd, Sahar Samy" uniqKey="Elabd S" first="Sahar Samy" last="Elabd">Sahar Samy Elabd</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Medicine, Benha University, Benha, Egypt.</nlm:affiliation><country xml:lang="fr">Égypte</country><wicri:regionArea>Faculty of Medicine, Benha University, Benha</wicri:regionArea><wicri:noRegion>Benha</wicri:noRegion></affiliation></author><author><name sortKey="Fathima, Samreen" sort="Fathima, Samreen" uniqKey="Fathima S" first="Samreen" last="Fathima">Samreen Fathima</name><affiliation wicri:level="1"><nlm:affiliation>Deccan College of Medical Sciences, University of Health and Sciences, Hyderabad, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Deccan College of Medical Sciences, University of Health and Sciences, Hyderabad</wicri:regionArea><wicri:noRegion>Hyderabad</wicri:noRegion></affiliation></author><author><name sortKey="Le Huy Vu, Tran" sort="Le Huy Vu, Tran" uniqKey="Le Huy Vu T" first="Tran" last="Le Huy Vu">Tran Le Huy Vu</name><affiliation wicri:level="2"><nlm:affiliation>University of California, Los Angeles, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of California, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Omrani, Ali S" sort="Omrani, Ali S" uniqKey="Omrani A" first="Ali S" last="Omrani">Ali S. Omrani</name><affiliation><nlm:affiliation>Department of Medicine, Section of Infectious Diseases, King Faisal Specialist Hospital and Research Centre, Riyadh, Kingdom of Saudi Arabia.</nlm:affiliation><wicri:noCountry code="subField">Kingdom of Saudi Arabia</wicri:noCountry></affiliation></author><author><name sortKey="Memish, Ziad A" sort="Memish, Ziad A" uniqKey="Memish Z" first="Ziad A" last="Memish">Ziad A. Memish</name><affiliation wicri:level="1"><nlm:affiliation>Ministry of Health, Riyadh, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Ministry of Health, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Hirayama, Kenji" sort="Hirayama, Kenji" uniqKey="Hirayama K" first="Kenji" last="Hirayama">Kenji Hirayama</name><affiliation wicri:level="1"><nlm:affiliation>Department of Immunogenetics, Institute of Tropical Medicine (NEKKEN), Leading Graduate School Program, and Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Immunogenetics, Institute of Tropical Medicine (NEKKEN), Leading Graduate School Program, and Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki</wicri:regionArea><wicri:noRegion>Nagasaki</wicri:noRegion></affiliation></author><author><name sortKey="Huy, Nguyen Tien" sort="Huy, Nguyen Tien" uniqKey="Huy N" first="Nguyen Tien" last="Huy">Nguyen Tien Huy</name><affiliation wicri:level="1"><nlm:affiliation>Evidence Based Medicine Research Group & Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City, Vietnam.</nlm:affiliation><country xml:lang="fr">Viêt Nam</country><wicri:regionArea>Evidence Based Medicine Research Group & Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City</wicri:regionArea><wicri:noRegion>Ho Chi Minh City</wicri:noRegion></affiliation></author></analytic><series><title level="j">Reviews in medical virology</title><idno type="eISSN">1099-1654</idno><imprint><date when="2018" type="published">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antiviral Agents (pharmacology)</term><term>Antiviral Agents (therapeutic use)</term><term>Coronavirus Infections (drug therapy)</term><term>Coronavirus Infections (mortality)</term><term>Coronavirus Infections (virology)</term><term>Female</term><term>Humans</term><term>Interferons (pharmacology)</term><term>Interferons (therapeutic use)</term><term>Male</term><term>Middle East Respiratory Syndrome Coronavirus</term><term>Risk Factors</term><term>Treatment Outcome</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Antiviraux (pharmacologie)</term><term>Antiviraux (usage thérapeutique)</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Infections à coronavirus (mortalité)</term><term>Infections à coronavirus (traitement médicamenteux)</term><term>Infections à coronavirus (virologie)</term><term>Interférons (pharmacologie)</term><term>Interférons (usage thérapeutique)</term><term>Mâle</term><term>Résultat thérapeutique</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term><term>Interferons</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiviral Agents</term><term>Interferons</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antiviraux</term><term>Interférons</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antiviraux</term><term>Interférons</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Female</term><term>Humans</term><term>Male</term><term>Middle East Respiratory Syndrome Coronavirus</term><term>Risk Factors</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Résultat thérapeutique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Middle East respiratory syndrome (MERS) is a respiratory disease caused by MERS coronavirus. Because of lack of vaccination, various studies investigated the therapeutic efficacy of antiviral drugs and supportive remedies. A systematic literature search from 10 databases was conducted and screened for relevant articles. Studies reporting information about the treatment of MERS coronavirus infection were extracted and analyzed. Despite receiving treatment with ribavirin plus IFN, the case fatality rate was as high as 71% in the IFN-treatment group and exactly the same in patients who received supportive treatment only. Having chronic renal disease, diabetes mellitus and hypertension increased the risk of mortality (P < .05), and chronic renal disease is the best parameter to predict the mortality. The mean of survival days from onset of illness to death was 46.6 (95% CI, 30.5-62.6) for the IFN group compared with 18.8 (95% CI, 10.3-27.4) for the supportive-only group (P = .001). Delay in starting treatment, older age group, and preexisting comorbidities are associated with worse outcomes. In conclusion, there is no difference between IFN treatment and supportive treatment for MERS patients in terms of mortality. However, ribavirin and IFN combination might have efficacious effects with timely administration and monitoring of adverse events. Large-scale prospective randomized studies are required to assess the role of antiviral drugs for the treatment of this high mortality infection.</div></front></TEI><affiliations><list><country><li>Arabie saoudite</li><li>Inde</li><li>Japon</li><li>Viêt Nam</li><li>Égypte</li><li>États-Unis</li></country><region><li>Californie</li><li>Pennsylvanie</li></region></list><tree><noCountry><name sortKey="Dat, Lu Minh" sort="Dat, Lu Minh" uniqKey="Dat L" first="Lu Minh" last="Dat">Lu Minh Dat</name><name sortKey="Kamel, Mohamed Gomaa" sort="Kamel, Mohamed Gomaa" uniqKey="Kamel M" first="Mohamed Gomaa" last="Kamel">Mohamed Gomaa Kamel</name><name sortKey="Mostafa, Mostafa Reda" sort="Mostafa, Mostafa Reda" uniqKey="Mostafa M" first="Mostafa Reda" last="Mostafa">Mostafa Reda Mostafa</name><name sortKey="Omrani, Ali S" sort="Omrani, Ali S" uniqKey="Omrani A" first="Ali S" last="Omrani">Ali S. Omrani</name><name sortKey="Thy, Tran Ngoc Xuan" sort="Thy, Tran Ngoc Xuan" uniqKey="Thy T" first="Tran Ngoc Xuan" last="Thy">Tran Ngoc Xuan Thy</name><name sortKey="Van Thanh, Le" sort="Van Thanh, Le" uniqKey="Van Thanh L" first="Le" last="Van Thanh">Le Van Thanh</name><name sortKey="Vuong, Nguyen Lam" sort="Vuong, Nguyen Lam" uniqKey="Vuong N" first="Nguyen Lam" last="Vuong">Nguyen Lam Vuong</name></noCountry><country name="Égypte"><noRegion><name sortKey="Morra, Mostafa Ebraheem" sort="Morra, Mostafa Ebraheem" uniqKey="Morra M" first="Mostafa Ebraheem" last="Morra">Mostafa Ebraheem Morra</name></noRegion><name sortKey="Ahmed, Sarah Ibrahim" sort="Ahmed, Sarah Ibrahim" uniqKey="Ahmed S" first="Sarah Ibrahim" last="Ahmed">Sarah Ibrahim Ahmed</name><name sortKey="Elabd, Sahar Samy" sort="Elabd, Sahar Samy" uniqKey="Elabd S" first="Sahar Samy" last="Elabd">Sahar Samy Elabd</name><name sortKey="Ghazy, Ahmed Abdelmotaleb" sort="Ghazy, Ahmed Abdelmotaleb" uniqKey="Ghazy A" first="Ahmed Abdelmotaleb" last="Ghazy">Ahmed Abdelmotaleb Ghazy</name></country><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Altibi, Ahmed M A" sort="Altibi, Ahmed M A" uniqKey="Altibi A" first="Ahmed M A" last="Altibi">Ahmed M A. Altibi</name></region><name sortKey="Le Huy Vu, Tran" sort="Le Huy Vu, Tran" uniqKey="Le Huy Vu T" first="Tran" last="Le Huy Vu">Tran Le Huy Vu</name></country><country name="Inde"><noRegion><name sortKey="Fathima, Samreen" sort="Fathima, Samreen" uniqKey="Fathima S" first="Samreen" last="Fathima">Samreen Fathima</name></noRegion></country><country name="Arabie saoudite"><noRegion><name sortKey="Memish, Ziad A" sort="Memish, Ziad A" uniqKey="Memish Z" first="Ziad A" last="Memish">Ziad A. Memish</name></noRegion></country><country name="Japon"><noRegion><name sortKey="Hirayama, Kenji" sort="Hirayama, Kenji" uniqKey="Hirayama K" first="Kenji" last="Hirayama">Kenji Hirayama</name></noRegion></country><country name="Viêt Nam"><noRegion><name sortKey="Huy, Nguyen Tien" sort="Huy, Nguyen Tien" uniqKey="Huy N" first="Nguyen Tien" last="Huy">Nguyen Tien Huy</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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